Members

Principal Investigators

Part A: Methods

A1 – Harald Schwalbe

Conformational dynamics of RNA regulation elements studied by NMR spectroscopy

A2 – Beatrix Suess

Development and characterization of engineered riboswitches

A3 – Thomas Prisner

Structure and conformational flexibility of RNA studied by EPR spectroscopy

A6 – Alexander Heckel

Light-responsive riboswitches and miRNA activity

A7 – Josef Wachtveitl

Molecular dynamics of RNA model systems studied by time-resolved optical and IR spectroscopy

A8 – Mike Heilemann

Quantitative mapping of synaptic molecules within single neurons using correlated super-resolution and electron microscopy (together with Erin Schuman)

A8 – Erin Schuman

Quantitative mapping of synaptic molecules within single neurons using correlated super-resolution and electron microscopy (together with Mike Heilemann)

A9 – Gerhard Hummer

Molecular Simulations of RNA Folding and Function

A11 – Nadine Schwierz

Regulating RNA by cations: Insight from MD simulations

Part B: Biological Systems

B2 – Stefanie Dimmeler

Hypoxia-controlled non-coding RNAs

B5 – Achilleas Frangakis

Visualization of the RNA-Polymerase III Complete Transcription Cycle and the Bacterial Expressome by Cryo-Electron Tomography

B7 – Robert Tampé

Control of mRNA translation and ribosome recycling by ABCE1

B9 – Enrico Schleiff

RNA and protein elements involved in plant ribosome biogenesis

B11 – Erin Schuman

New tools to study the dynamics of RNA and RNP distribution in neuronal cells (together with Alexander Heckel)

B11 – Alexander Heckel

New tools to study the dynamics of RNA and RNP distribution in neuronal cells (together with Erin Schuman)

B12 – Martin Hengesbach

Structural dynamics of eukaryotic H/ACA RNPs

B13 – Michaela Müller-McNicoll

Dissecting the regulatory mechanisms of alternative polyadenylation and nuclear retention of mRNAs by SR proteins (together with Kathi Zarnack)

B13 – Kathi Zarnack

Dissecting the regulatory mechanisms of alternative polyadenylation and nuclear retention of mRNAs by SR proteins (together with Michaela Müller-McNicoll)

B14 – Julia Weigand

High-throughput identification of conserved structures in mRNAs

B15 – Andreas Krueger

Identification of miRNAs Targeting Hierarchies in Lymphocyte Development

B16 – Andreas Schlundt

Target cis elements of the RNA-binding protein Arid5a in inflammatory cytokine-based diseases

B17 – Jens Wöhnert

Function, mechanism and structural basis for the regulation of gene expression by small regulatory RNAs (sRNAs) in gamma-proteobacteria (together with Helge B. Bode)

B17 – Helge B. Bode

Function, mechanism and structural basis for the regulation of gene expression by small regulatory RNAs (sRNAs) in gamma-proteobacteria (together with Jens Wöhnert)

B18 – Covid19-NMR

The aim of the international Covid19-NMR project is to determine RNA and protein structures of SARS-CoV-2 and to investigate the drugability of those structures by small molecules. The resulting data will be made publicly available by weekly updates throughout the project prior to publication.

B19 – Simon Trowitzsch

Structural and mechanistic basis of pre-tRNA processing by the human tRNA splicing endonuclease in health and neurodegenerative disease