Conformational dynamics of RNA regulation elements studied by NMR spectroscopy
Project A1 focuses on NMR-spectroscopic characterization of riboswitch RNAs. We aim to understand riboswitches in increasingly complex environment, starting from isolated aptamer domains in vitro towards the translation initiation machinery in vivo. To gain high-resolution structural information of these macromolecular complexes, we develop biochemical methods such as site-specific modification of single nucleotides, and NMR-spectroscopic methods, such as hetero-nuclei direct-detected experiments. Exemplified by further regulative RNAs we demonstrate the broad applicability of our methods in the field of RNA-based regulation. More
Webpage
Phone
ORCID
Address
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 7
60438 Frankfurt am Main.
Co-Workers on RNA
Tom Landgraf
PhD. Student
RNA, riboswitches, screening
Email: landgraf@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29931
Building: N160/316
Albrecht Völklein
PhD. Student
RNA, riboswitches, NMR
Email: voelklein@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29934
Building: N160/308
Diana Müller
PhD. Student
NMR studies of G-quadruplexes dynamics and ligand interaction
Email: mueller@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29934
Building: N160/308
Alexey Sudakov
PhD. Student
Chemo-enzymatic synthesis of site-specific labelled RNAs for NMR
Email: sudakov@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29956
Building: N160/300
Tobias Matzel
PhD. Student & sfb902 student speaker
NMR of RNA, RNA binding proteins, paramagnetic NMR
Email: matzel@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29932
Building: N140/304
Tatjana Schamber
PhD. Student
NMR structural characterization of RNA
Email: schamber@nmr.uni-frankfurt.de
ORCID: 0000-0001-9312-7243
Phone: +49(0) 69 798 29956
Building: N160/300
Julius Blechar
PhD. Student
Email: blechar@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29931
Building: N160/316
Vanessa de Jesus
PhD. Student
RNA structure, ribosomes, translation
Email: dejesus@nmr.uni-frankfurt.de
Phone: +49(0) 69 798 29931
Building: N160/316
Twitter: @JesusVanessa17
