Regulating RNA by Cations – Insights from Molecular Simulations
Positively charged cations are essential for the stability and function of RNA. In particular, changes in the local salt concentration or the type of cations present in solution immediately influence RNA regulatory elements and their regulatory functions. We will apply molecular dynamics simulations to elucidate the fundamental interplay of cations and RNA regulation. We will focus on the mechanism of ion selectivity and exchange for the example of an RNA G-quadruplex. In addition, we aim to resolve the mechanism of cation sensing of the guanidine-II riboswitch. More
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Co-Workers on RNA
Sergio Cruz-León
Ph.D Student
Molecular dynamics simulations on the effects of RNA and metal cations
Email: sergio.cruz@biophys.mpg.de
Twitter: @SergioCruzLeon1
ORCID: 0000-0003-1256-2206
Kara Grotz
Ph.D Student
Development of accurate force fields for Mg2+ in combination with RNA
Email: kara.grotz@biophys.mpg.de
ORCID: 0000-0002-3075-7958
Marijana Ugrina
Ph.D Student
Role of metal cations in regulation of RNA quadruplexes