Molecular dynamics of RNA model systems studied by time-resolved optical and IR spectroscopy
The vital role of RNA structure and conformational dynamics for its biological functionality is increasingly recognized. Therefore we develop systems and methodologies to obtain a time- and site-resolved picture of the functional dynamics of various regulatory RNAs. Specific spectroscopic labels allow to monitor folding and hybridization dynamics. Photoswitchable RNA-ligand-systems based on azobenzene or spiropyran units or photocaged circularized RNAs provide the necessary spatial and temporal resolution to trigger and observe these processes and to elucidate the underlying mechanisms. More
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Institute of Physical and Theoretical Chemistry
Max von Laue-Straße 7
Building N120/224
D-60438 Frankfurt am Main
Co-Workers on RNA
Christoph Kaiser
Postdoc
Structural RNA dynamics, Light-controlled RNA systems
Email: kaiser@theochem.uni-frankfurt.de
Phone: +49(0) 69 798 29448
Building: N120/227
Florian Hurter
PhD. Student
RNA binding dynamics
Email: hurter@theochem.uni-frankfurt.de
Building: N120/227
Konstantinos Stamatakis
SFB908 student speaker
Structual RNA binding dynamics, fluorogenic Aptamers
Email: stamatakis@theochem.uni-frankfurt.de
Phone: +49(0) 69 798 29635
Building: N120/215