New tools to study the dynamics of RNA and RNP distribution in neuronal cells
In the 2nd funding period, we were able to show that pre-miR181a is processed locally by Dicer upon local synaptic activity in neurons. This work demonstrated for the first time that miRNAs can be generated by extracellular signals (like neurotransmitters) in remote cellular regions like dendrites. In the upcoming funding period, we now want to fully understand this regulatory system – especially its spatio-temporal aspects. To this end we will design and apply probes for the quantitative super-resolution imaging of the key players of this regulatory system. In a second part of the project we will investigate a newly discovered process of active 3’-UTR shortening of mRNA in neuronal dendrites. We will try to control this process with light and visualize it in real-time upon external stimulation. More
Phone
ORCID
Google Schoolar
+49(0) 69 850033 1000
Address
Goethe Universität Frankfurt
Max-von-Laue-Str. 7
60438 Frankfurt am Main
Building N160/416
Max Planck Institute for Brain Research
Max-von-Laue-Str. 4
L.1.021
60438 Frankfurt am Main
Germany
Co-Workers on RNA
