Part A is devoted to the development and optimization of new methods for the investigation of RNA properties and function. These novel tools will be applied to understand the role of specific structural elements and conformational dynamics to induce regulatory functions of RNA, from model systems to riboswitch RNA. The developed tools will also be applied to systems defined in Part B, encompassing important RNA-protein complexes (RNP).
A1 – Harald Schwalbe
Conformational dynamics of RNA regulation elements studied by NMR spectroscopy
A2 – Beatrix Süß
Development and characterization of engineered riboswitches
A3 – Thomas Prisner
Structure and conformational flexibility of RNA studied by EPR spectroscopy
A6 – Alexander Heckel
Light-responsive riboswitches and miRNA activity
A7 – Josef Wachtveitl
Molecular dynamics of RNA model systems studied by time-resolved optical and IR spectroscopy
A8 – Mike Heilemann & Erin Schuman
Quantitative mapping of synaptic molecules within single neurons using correlated super-resolution and electron microscopy
A9 – Gerhard Hummer
Molecular Simulations of RNA Folding and Function
A11 – Nadine Schwierz
Regulating RNA by cations: Insight from MD simulations